dsRNA Virus Model Molecule and the Mechanism of PRRs and its Research Progress in Female Reproductive Tract Infections

dsRNA and PRRs in female genital tract infection

  • Yuting Pan Sichuan water conservancy vocational College, China
  • Yan Zhang Sichuan Water Conservancy Vocational College, China
  • Xiaoxu Li Sichuan Water Conservancy Vocational College, China
  • Juping Li Zigong Center for Disease Control and Prevention, China
  • Ling Xu Sichuan Agricultural University, China
  • Wencan Wang Sichuan Agricultural University, China
  • Min Cui Sichuan Agricultural University, China
  • Mingwu Tian Sichuan Water Conservancy Vocational College, China
DOI: https://doi.org/10.61797/ijbca.v1i1.48
Keywords: Genital tract infection, dsRNA, PRRs, Signal transduction

Abstract

Female animal genital tract opening on the body surface, prone to bacterial, viral, parasitic, and other pathogenic microorganism infections, leading to genital tract infectious diseases, such as endometritis, cervicitis, vaginitis, etc. Severe infection can lead to infertility, abortion, and even fetal death. Double-stranded RNA (dsRNA) is an important model molecule, which is widely present in the genome of viruses and generated in the process of virus replication. In mammals, dsRNA is considered to be an innate immune response signal for viral infection, which binds to the corresponding pattern-recognition receptors (PRRs) In vivo and then exerts biological functions. This review summarizes the signal transduction pathway induced by the binding of dsRNA model molecules to PRRs, research status of female genital tract infections and research progress of dsRNA in simulating viral infection in the female genital tract.

Published
2021-02-26
Issue
Vol 1 No 1 (2021): Int J Biomed Clin Anal
Section
Articles

Copyright (c) 2021 Yuting Pan, Yan Zhang, Xiaoxu Li, Juping Li, Ling Xu, Wencan Wang, Min Cui, Mingwu Tian

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Copyright © by the authors; licensee Research Lake International Inc., Canada. This open-access article is distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC) (http://creative-commons.org/licenses/by-nc/4.0/).